NASA's Earth Science Applications Guidebook is a web-based, multimedia product synthesizing best practices and lessons learned on the use of Earth science information for decision-making. This online guidebook mixes interactive features with multimedia content to provide explain the uses of Earth science information, practical guidance on all steps of developing an application, and scientist perspectives on what it takes to succeed. Unlike a traditional "book-style" manual or guide, the guidebook offers multiple entry pathways that enable a user to choose various learning experiences depending on their interests. From climate change, biodiversity, disaster management, and other challenges, the guidebook draws on the wealth of knowledge and passion of scientists who have dedicated their careers to using Earth science data. The guidebook is designed to be visually appealing, easy to navigate, and offers practical, usable approaches to help applications teams deliver more effective, impactful tools, datasets, models, and other applications for decision-making. By capturing the great diversity of program areas, geographies, and people engaged in this important work, this guidebook captures the power of Earth science information to improve lives, solve pressing problems, and inspire a new generation of audiences to pursue applied Earth science. The Earth Science Applications Guidebook can be found at the NASA Earth Applied Sciences Program website: https://appliedsciences.nasa.gov/guidebook/