Clinical features (sympathetic overactivity): Behavior disturbances Weight loss Goiter Proptosis Tachycardia, wide pulse pressure Tremor, hyperreflexia Warm, sweaty skin Diagnosis: ↑ T3/T4, ↓ TSH TSI (thyroid-stimulating immunoglobulin, Graves disease) Treatment / management: Methimazole ± Radioactive iodine Complications: Arrhythmia, cardiomyopathy Osteoporosis