Full Titile: Microfluidic Elaboration of Polymeric Micro-carriers with Complex Morphologies for New Drug Delivery Strategies Abstract: Microencapsulation is used for the protection of drug, controlled release, reduced administration frequency, patient comfort and compliance. In comparison with conventional techniques for encapsulation, microfluidics offers a new route to precisely control over microcarriers’ size, shape, morphology, composition and thus release properties. Continuous-flow off-the-shelves capillaries-based microfluidic droplet generators, assembled within minutes [1], were used to produce size-controlled and drug-loaded plain, core-shell, Janus and Trojan polymeric microcarriers. A single capillary-based device was employed to obtained either poly(ethyl acrylate) plain microparticles [2] or poly(acrylamide) Trojan microparticles embedding with drug-loaded poly(ethyl acrylate) nanoparticles previously obtained from the nanoemulsification of the monomer phase with an elongation-flow micromixer [3]. On the opposite, a two capillaries-based device was employed to prepare poly(acrylamide)/poly(methyl acrylate) core-shell [4] and Janus [5] microparticles encapsulating two incompatible drug in two spate domain. This lecture proposes to study the production and the release properties of these microcarriers as well as the subsequent new release strategies (e.g., sequential, synergetic, nanoparticle delivery to GIT etc.) arising from these uncommon morphologies. It will be demonstrated how operating parameters (fluids’ flow rate, nature of the monomer, concentration of the surfactant etc.) can affect the size and the morphology of the polymeric microcarriers and how to tune the sustained release of a single drug or two incompatible drugs encapsulated into a single microparticle. Keywords: Microfluidics, polymer, microparticles, drug, delivery Full Article: https://www.proceedings.iaamonline.org/article/vpoam-2021-02101 Join us: https://www.iaamonline.org/