High dose creatine for brain function - memory, depression, alzheimers High dose creatine (between 10g to 30g a day) seems to have no negative side effects - some studies have used it for over 5 years! I personally take 10g twice per day (morning and night) with food and have done so for over 15 years. With all of the research on it's effects on memory, mood and neuroprotective benefits, for me it's a no-brainer. If you want to do some testing on yourself to see if it has any noticeable benefit, look up the "Stroop Test" online as a simple way to test your cognitive function before taking/increasing your dose, then retest it after 1-2 weeks in similar conditions. Main Reference: The effects of creatine supplementation on cognitive function in adults: a systematic review and meta-analysis - PMID: 39070254 PS - please don't snort your creatine 😂