Around one in every 10 people will suffer from depression. Brain regions that control mood are often disrupted in depression. Antidepressant drugs or behavioral therapy can offer some relief. By understanding the brain better, our ability to treat depression should also get a boost. Watch the video to learn about the neural circuits affected in depression, and the molecular and cellular changes that might hold the key to treating it. Created by the editors at Nature Neuroscience: http://www.nature.com/neuro/index.html Nature has full responsibility for all editorial content, including Nature Video content. This content is editorially independent of sponsors. Sign up for the Nature Briefing: An essential round-up of science news, opinion and analysis, free in your inbox every weekday. https://go.nature.com/371OcVF