Sacred Heart Hospital has seen its fair share of familiar faces, some of which you might barely remember. From legends like Dick Van Dyke to Hollywood A-listers like Ryan Reynolds, these guest stars brought extra charm and surprises to Scrubs. Many of them took on memorable roles in just a few episodes, showcasing their comedic timing and dramatic chops. With appearances from Colin Farrell, Heather Graham, Matthew Perry, Brendan Fraser, Mandy Moore, and more, this list is a nostalgic reminder of the star-studded moments that made Scrubs such a beloved series. Can you think of any other memorable guest stars? Let us know in the comments! FOLLOW all our socials for more content here: https://linktr.ee/msmojo Don't forget to play our Live Trivia games at 3pm EST for a chance to win cash! The faster you answer, the more points you get!: https://www.watchmojo.com/play MsMojo is a leading producer of reference online video content of Top 10 Lists, Origins, Biographies, Commentary and more on Pop Culture, Celebrity, Movies, Music, TV, Film, Video Games, Politics, News, Comics, Superheroes. Your trusted authority on ranking Pop Culture. #Scrubs #RyanReynolds #ColinFarrell #DickVanDyke #MatthewPerry #MichaelJFox #MandyMoore #BrendanFraser #JasonBateman