10. Platforms for Targeting, Drug Delivery, Diagnostics, Drug Development, Design Strategies and Manufacturing for Precision Medicine (12’ Speech and 3’ Questions) In the last years, many different systems and strategies have been developed for drug targeting to pathological sites, as well as for visualizing and quantifying important physiological processes. Seen as ultimate goal to come to clinical outcomes the production and application of nanoparticles in health bears challenges with respect to assessing efficacy, quality and safety. Machine learning and artificial intelligence are in development and could accelerate the lifecycle and the scientific guidance for nanomedical products. A drug delivery system must execute multiple tasks, involving the highest degree of smartness. In the last years, many different systems and strategies have been developed for drug targeting to pathological sites, as well as for visualizing and quantifying important physiological processes. Chair Dr. Marieluise Wippermann, CEO, TecoMedical Ltd, Sissach (CH) 08.15 The Digital Twin, an Essential Tool in Personalizing Therapy and Prevention Prof. Dr. Hans Lehrach, Director, Head, Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin (D) 08.30 Barcoded Cancer Nanomedicines and Nano Immunotherapies Perform Differently in the Primary Tumor and in the Metastasis Prof. Dr. Avi Schroeder, PhD, Associate Professor of Chemical Engineering Laboratory for Targeted Drug Delivery and Personalized Medicine Technologies, Technion ‐ Israel Institute of Technology, Haifa (IL) Nanoparticle Design Strategies for Effective Liver Cancer Immunotherapy Prof. Dr. Gerrit Borchard, Translational Research Centre in Oncohaematology, Biopharmaceutical Science Group Leader, CRTOH associate member, Geneva-Lausanne School of Platformability of RNA Drug Delivery; the Case of EXPERT, Bringing Immune Activating mRNA to the Clinic Dr. Sven Even Borgos, Senior Research Scientist, SINTEF Materials and Chemistry, Department of Biotechnology and Nanomedicine, Trondheim (N) Questions and Debate