Dr. Katharina Wittfeld, a Post-Doctoral Researcher at the German Center for Neurodegenerative Diseases (DZNE) and the University Medicine Greifswald, Germany, reviews her article appearing in the January 2020 issue of Mayo Clinic Proceedings, on the association of cardiorespiratory fitness with brain volumes. The authors found that cardiorespiratory fitness was positively associated with gray matter volume, total brain volume, and specific gray matter clusters in brain areas not primarily involved in movement processing, which suggests that cardiorespiratory fitness might contribute to improved brain health and decelerated pathology-specific gray matter decrease. . Available at: https://mayocl.in/2qkY8sZ