While newer drugs like Pregabalin and Gabapentin are common, let's not forget a reliable and cost-effective classic: Amitriptyline. For many of our patients, especially in tier 2 settings, it's still a highly effective option for neuropathic pain. Here are the key clinical takeaways from the reel: ✅ Dosing Strategy: Start low at 10mg, preferably at night. The goal is to gradually titrate up to the effective therapeutic dose of 25-75mg over a week or two. ✅ Timing is Key: Administer at night. Its primary side effect, sedation, can be used to the patient's advantage by helping with sleep, which is often disturbed by chronic pain. ✅ Patient Counseling is CRUCIAL: Anticholinergic effects: Warn them about dry mouth, dry eyes, and potential urinary retention. Other common effects: Mention the possibility of weight gain and the need to monitor for pedal edema during follow-up. 💡 Here's a question for our community: The video asks about a key cardiac side effect of TCAs like Amitriptyline. What's the main thing you monitor for on an ECG? Share your thoughts and experiences in the comments! 👇 #ClinicalPearls #DoctorsOfIndia #MedicalEducation #NeuropathicPain #PainManagement #Amitriptyline #IndianDoctors #Pharmacology